Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• innovative biomedical strategies mainly in the field of anticancer therapy. Keywords: nucleopeptides; poly(rA) binders; RNA; self-structures; Review Polyadenylation in RNA processing Polyadenylation is part of the RNA processing pathway that leads to the production of mature mRNA molecules (Figure 1) [1

• proteins in the cell, thus leading to new therapeutic strategies based on poly(rA) binders [15]. Interestingly, nuclear endogenous poly(rA) was tagged in living cells using fluorescently labelled oligo(dT) as a hybridization probe to study the movement of RNA through the interchromatin space [16

• are able to bind poly(rA) could be able in principle to interfere also with the translation process, both in healthy and neoplastic cells. However, the selective inhibition of protein translation in neoplastic cells with respect to normal cells by poly(rA) binders of different nature is currently